منابع مشابه
TP53 and liver carcinogenesis.
Primary hepatocellular carcinoma (HCC) is one of the most common malignancies and has the fourth highest mortality rate worldwide. The major risk factors, including chronic infections with the hepatitis B or C virus, are exposure to dietary aflatoxin B1(AFB1), vinyl chloride, or alcohol consumption. Southern China and sub-Saharan Africa have the highest dietary AFB1 exposure, making it and hepa...
متن کاملThe role of TP53 in Cervical carcinogenesis.
Functional loss of the tumor suppressor p53 by alterations in its TP53 gene is a frequent event in cancers of different anatomical regions. Cervical cancer is strongly linked to infection by high-risk human papillomavirus (HPV) types. The viral oncoprotein E6 has the ability to associate with and neutralize the function of p53. E6 interacts with a 100-kDa cellular protein, termed E6 associated ...
متن کاملAlterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis
TP53 genes is one of more important tumor suppressor gene, which acts as a potent transcription factor with fundamental role in the maintenance of genetic stability. The development of esophageal and gastric cancers is a multistep process resulting in successive accumulation of genetic alterations that culminates in the malignant transformation. Thus, this study highlights the participation of ...
متن کاملLiver Development, Regeneration, and Carcinogenesis
The identification of putative liver stem cells has brought closer the previously separate fields of liver development, regeneration, and carcinogenesis. Significant overlaps in the regulation of these processes are now being described. For example, studies in embryonic liver development have already provided the basis for directed differentiation of human embryonic stem cells and induced pluri...
متن کاملPromoting Stage of Lung and Skin Carcinogenesis in Mice Carcinogenesis: Spontaneous Liver Carcinogenesis
Although B-carotene has been considered to be a key cancer preventive agent in green and yellow vegetables, other types of carotenoids, such as a-carotene, may also contribute to anticarcinogenic action, since these carotenoids usually coexist with/~-carotene and are detectable in human blood and tissues. In this study, we compared the inhibitory effect of natural a-carotene, obtained from palm...
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ژورنال
عنوان ژورنال: Human Mutation
سال: 2003
ISSN: 1059-7794,1098-1004
DOI: 10.1002/humu.10176